Antinociceptive effects of fluoxetine and paroxetine with their related actions on glycemia in mice


Kesim M. , Duman E. N. , Kadioglu M. , Ulku C., Muci E., Kalyoncu N. I. , ...More

NEUROENDOCRINOLOGY LETTERS, vol.27, no.1-2, pp.281-287, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 1-2
  • Publication Date: 2006
  • Title of Journal : NEUROENDOCRINOLOGY LETTERS
  • Page Numbers: pp.281-287
  • Keywords: paroxetine, fluoxetine, blood glucose levels, diabetes, streptozotocin, antinociception, mice, SEROTONIN REUPTAKE INHIBITORS, PLACEBO-CONTROLLED TRIAL, MECHANICAL HYPERALGESIA, INDUCED HYPERGLYCEMIA, DIABETIC-NEUROPATHY, DOUBLE-BLIND, PAIN RELIEF, DEPRESSION, ANTIDEPRESSANTS, STREPTOZOTOCIN

Abstract

OBJECTIVES: Clinical and experimental trials have demonstrated that some of selective serotonin reuptake inhibitors (SSRIs) have some suspicious effects on blood glucose levels in different directions. Especially fluoxetine and sertraline are studied in this point of view. These drugs are also used in treatment of depression and peripheral neuropathy in diabetic patients. Paroxetine and fluoxetine, members of this drug group, besides having antidepressant effects were shown to have antinociceptive effects in animals and humans. They can be used in the treatment of chronic pain as an adjuvant drug or alone. But less is known about their actions on pain in case of diabetes. The aim of this study is to investigate the antinociceptive effects of fluoxetine and paroxetine in diabetic and non-diabetic mice while monitoring their effects on blood glucose levels.