The effect of Simvastatin on Picrotoxin-induced seizure in mice

KESIM M., YULUĞ E., KADIOGLU M., ERKOSEOGLU İ., AYKAN D. A., KALYONCU N. İ., ...More

JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION, vol.62, no.11, pp.1187-1191, 2012 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 62 Issue: 11
  • Publication Date: 2012
  • Journal Name: JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1187-1191
  • Keywords: Seizures, Simavastain, Picrotoxin, HIPPOCAMPAL CELL-DEATH, ACID-INDUCED SEIZURES, NEURONAL INJURY, RECEPTOR ACTIVATION, GLUCOSE DEPRIVATION, CORTICAL-NEURONS, GLUTAMATE UPTAKE, EXCITOTOXICITY, ATORVASTATIN, MECHANISMS
  • Karadeniz Technical University Affiliated: Yes

Abstract

Objective: To study the effect of simvastatin on picrotoxin-induce seizures in mice in order to understand the impact of gabaergic system on neuronal cell death.