The effect of Simvastatin on Picrotoxin-induced seizure in mice

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KESIM M., YULUĞ E., KADIOGLU M., ERKOSEOGLU İ., AYKAN D. A., KALYONCU N. İ., ...More

JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION, vol.62, no.11, pp.1187-1191, 2012 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 62 Issue: 11
• Publication Date: 2012
• Journal Name: JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1187-1191
• Keywords: Seizures, Simavastain, Picrotoxin, HIPPOCAMPAL CELL-DEATH, ACID-INDUCED SEIZURES, NEURONAL INJURY, RECEPTOR ACTIVATION, GLUCOSE DEPRIVATION, CORTICAL-NEURONS, GLUTAMATE UPTAKE, EXCITOTOXICITY, ATORVASTATIN, MECHANISMS
• Karadeniz Technical University Affiliated: Yes

Abstract

Objective: To study the effect of simvastatin on picrotoxin-induce seizures in mice in order to understand the impact of gabaergic system on neuronal cell death.