The effect of Simvastatin on Picrotoxin-induced seizure in mice

KESIM M., YULUĞ E., KADIOGLU M., ERKOSEOGLU İ., AYKAN D. A., KALYONCU N. İ., ...Daha Fazla

JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION, cilt.62, sa.11, ss.1187-1191, 2012 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 11
  • Basım Tarihi: 2012
  • Dergi Adı: JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1187-1191
  • Anahtar Kelimeler: Seizures, Simavastain, Picrotoxin, HIPPOCAMPAL CELL-DEATH, ACID-INDUCED SEIZURES, NEURONAL INJURY, RECEPTOR ACTIVATION, GLUCOSE DEPRIVATION, CORTICAL-NEURONS, GLUTAMATE UPTAKE, EXCITOTOXICITY, ATORVASTATIN, MECHANISMS
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Objective: To study the effect of simvastatin on picrotoxin-induce seizures in mice in order to understand the impact of gabaergic system on neuronal cell death.