The effect of Simvastatin on Picrotoxin-induced seizure in mice

KESIM M. , YULUĞ E. , KADIOGLU M., ERKOSEOGLU İ. , AYKAN D. A. , KALYONCU N. İ. , ...More

JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION, vol.62, no.11, pp.1187-1191, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 11
  • Publication Date: 2012
  • Title of Journal : JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
  • Page Numbers: pp.1187-1191
  • Keywords: Seizures, Simavastain, Picrotoxin, HIPPOCAMPAL CELL-DEATH, ACID-INDUCED SEIZURES, NEURONAL INJURY, RECEPTOR ACTIVATION, GLUCOSE DEPRIVATION, CORTICAL-NEURONS, GLUTAMATE UPTAKE, EXCITOTOXICITY, ATORVASTATIN, MECHANISMS

Abstract

Objective: To study the effect of simvastatin on picrotoxin-induce seizures in mice in order to understand the impact of gabaergic system on neuronal cell death.