Objective. Graves' disease is an organ-specific autoimmune disease with unknown etiology. TSHR Ab plays the most important role for the pathogenesis of Graves' disease. Recently, the role of cytokines for the pathogenesis of Graves' disease has been studied extensively. Royal jelly (1111) is a creamy product secreted by young nurse worker bees (Apis mellifera), and it is synthesized in the hypopharyngeall and mandibular glands. R) has been reported to have such pharmacological characteristics as antitumor, antibacterial, antihyper-cholesterolemic, antiallergic, antiinflammatory, and immunomodulatory properties. The major aim of the present study is to evaluate the effect of RJ on autoimmunity in peripheral lymphocyte culture and to establish the therapeutic doses.