Synthesis and <i>In Vitro</i> Antioxidant Evaluation of Some Novel 4, 5-Dihydro-1<i>H</i>-1, 2, 4-triazol-5-one Derivatives

GÜRSOY KOL Ö., Yuksek H.

E-JOURNAL OF CHEMISTRY, cilt.7, sa.1, ss.123-136, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1155/2010/407603
  • Dergi Adı: E-JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.123-136
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

In this study, thirteen novel 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives were synthesized and characterized by elemental analyses and IR, H-1 NMR, C-13 NMR and UV spectral data. The synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods. Those antioxidant activities were compared to standard antioxidants such as BHA, BHT and alpha-tocopherol. The data reveal that the compounds demonstrate a marked capacity for iron binding, especially 5a and 7c. In addition to this, the compounds 4 were titrated potentiometrically with TBAH in non-aqueous solvents because of the weak acidic properties of 4,5-dihydro-1H-1,2,4-triazol-5-one ring N-H group.