Autoantibodies Against Carbonic Anhydrase I and II in Patients with Acute Myeloid Leukemia

MENTEŞE A., ERKUT N., DEMİR S., ÖZER YAMAN S., Sumer A., DOĞRAMACI Ş., ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.34, no.4, pp.307-313, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.4274/tjh.2016.0341
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.307-313
  • Karadeniz Technical University Affiliated: Yes

Abstract

Objective: Cancer, one of the principal causes of death, is a global social health problem. Autoantibodies developed against the organism's self-antigens are detected in the sera of subjects with cancer. In recent years carbonic anhydrase (CA) I and II autoantibodies have been shown in some autoimmune diseases and carcinomas, but the mechanisms underlying this immune response have not yet been explained. The aim of this study was to evaluate CA I and II autoantibodies in patients with acute myeloid leukemia (AML) and to provide a novel perspective regarding the autoimmune basis of the disease.