Hepatitis B core antigen expression pattern reflects the response to anti-viral treatment

Uzun Y., Bozkaya H., Erden E., Cinar K., Idilman R., Yurdaydin C., ...More

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.21, no.6, pp.977-981, 2006 (SCI-Expanded) identifier identifier identifier


Background: In hepatitis B early antigen (HBeAg)-negative patients, response predictors to current treatment regimens are not well known. Hepatocyte cell cycle may influence hepatitis B virus (HBV) replication and hepatitis B core antigen (HBcAg) expression, which is a major target for antiviral immune response. The aim of the present paper was to evaluate the role of HBcAg expression in liver tissue and the rate of hepatocyte proliferation in response to antiviral treatment in chronic hepatitis B.