Hepatitis B core antigen expression pattern reflects the response to anti-viral treatment


Uzun Y., Bozkaya H., Erden E., Cinar K., Idilman R., Yurdaydin C., ...More

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.21, no.6, pp.977-981, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 6
  • Publication Date: 2006
  • Doi Number: 10.1111/j.1440-1746.2006.04263.x
  • Title of Journal : JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Page Numbers: pp.977-981

Abstract

Background: In hepatitis B early antigen (HBeAg)-negative patients, response predictors to current treatment regimens are not well known. Hepatocyte cell cycle may influence hepatitis B virus (HBV) replication and hepatitis B core antigen (HBcAg) expression, which is a major target for antiviral immune response. The aim of the present paper was to evaluate the role of HBcAg expression in liver tissue and the rate of hepatocyte proliferation in response to antiviral treatment in chronic hepatitis B.