THE EFFECT OF INDOMETHACIN ON CYCLOSPORINE-A AND ITS SOLVENT-INDUCED INHIBITION OF ENDOTHELIUM-DEPENDENT RELAXATION AND THE DRUG-INDUCED CONTRACTION OF RABBIT ISOLATED ARTERIES
GENERAL PHARMACOLOGY, vol.26, no.1, pp.93-97, 1995 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 26 Issue: 1
- Publication Date: 1995
- Doi Number: 10.1016/0306-3623(94)00168-m
- Journal Name: GENERAL PHARMACOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.93-97
- Keywords: CYCLOSPORINE, CREMOPHOR-EL, VASCULAR SMOOTH MUSCLE, RABBIT THORACIC AORTA, RABBIT MESENTERIC ARTERY, INDOMETHACIN, NITRIC OXIDE, SPONTANEOUSLY HYPERTENSIVE RAT, AORTA, CELLS, NEPHROTOXICITY, ACETYLCHOLINE, MECHANISM, RESPONSES, RELEASE
- Karadeniz Technical University Affiliated: No
Abstract
1. In the isolated rabbit arteries, the effects of intravenous cyclosporin A preparation (Sandimmun) and its solvent (Cremophor-EL) on acetylcholine-induced endothelium-dependent relaxation were investigated in the absence and presence of indomethacin (10(-5) M), a cyclooxygenase inibitor.