THE EFFECT OF INDOMETHACIN ON CYCLOSPORINE-A AND ITS SOLVENT-INDUCED INHIBITION OF ENDOTHELIUM-DEPENDENT RELAXATION AND THE DRUG-INDUCED CONTRACTION OF RABBIT ISOLATED ARTERIES

YARIS E., TUNCER M.

GENERAL PHARMACOLOGY, cilt.26, sa.1, ss.93-97, 1995 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 1
  • Basım Tarihi: 1995
  • Doi Numarası: 10.1016/0306-3623(94)00168-m
  • Dergi Adı: GENERAL PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.93-97
  • Anahtar Kelimeler: CYCLOSPORINE, CREMOPHOR-EL, VASCULAR SMOOTH MUSCLE, RABBIT THORACIC AORTA, RABBIT MESENTERIC ARTERY, INDOMETHACIN, NITRIC OXIDE, SPONTANEOUSLY HYPERTENSIVE RAT, AORTA, CELLS, NEPHROTOXICITY, ACETYLCHOLINE, MECHANISM, RESPONSES, RELEASE
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

1. In the isolated rabbit arteries, the effects of intravenous cyclosporin A preparation (Sandimmun) and its solvent (Cremophor-EL) on acetylcholine-induced endothelium-dependent relaxation were investigated in the absence and presence of indomethacin (10(-5) M), a cyclooxygenase inibitor.