Neuroimmunophilin ligands protect cavernous nerves after crush injury in the rat: New experimental paradigms

VALENTINE H., CHEN Y., GUO H., MCCORMICK J., WU Y., Sezen S. F., ...More

EUROPEAN UROLOGY, vol.51, no.6, pp.1724-1731, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 6
  • Publication Date: 2007
  • Doi Number: 10.1016/j.eururo.2006.11.026
  • Journal Name: EUROPEAN UROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1724-1731
  • Keywords: cavernous nerve injury, erectile dysfunction, immunophilin ligands, ENDOTHELIAL GROWTH-FACTOR, IMMUNOPHILIN-LIGANDS, RADICAL PROSTATECTOMY, ERECTILE DYSFUNCTION, NEUROTROPHIC FACTOR, IN-VIVO, REGENERATION, MODEL, RECOVERY, FK506
  • Karadeniz Technical University Affiliated: No

Abstract

Objectives: We investigated the effects of the orally bioavailable nonimmunosuppressive immunophilin ligand GPI 1046 (GPI) on erectile function and cavernous nerve (CN) histology following unilateral or bilateral crush injury (UCI, BCI, respectively) of the CNs.