Akademik Veri Yönetim Sistemi
Revista de Psiquiatria Clinica, cilt.48, sa.1, ss.16-19, 2021 (SCI-Expanded)
Background: Nesfatin-1 is an anorexigenic protein expressed in the hypothalamus. Besides the effect on appetite, nesfatin-1 has some effect on mood. In this study, we aimed to investigate the relationship between serum nesfatin-1 levels and major depressive disorder in adolescents diagnosed as major depressive disorder. Methods: A total of 30 patients between the ages of 12 and 18 with primary diagnosis of major depressive disorder have been included. Depressive scores of both groups were measured by the Children’s Depression Inventory. Serum nesfatin-1 concentrations were measured by a commercially available kit based on the enzyme-linked immunosorbent assay (ELISA) method. Results: The mean serum nesfatin-1 levels in patients with MDD was 40.11±1.62 pg/ml, whereas it was 37.51±5.10 pg/ml in healthy controls. Mean serum nesfatin-1 levels difference between groups was statistically significant. There is a positive correlation between serum nesfatin-1 levels and CDI scores in the whole sample. Discussion: This is the first study to examine the relationship between major depressive disorder and serum nesfatin-1 levels in adolescents diagnosed as major depressive disorder. Further studies are needed to clarify this relationship.