A study on novel 4-heteroarylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-ones


Yuksek H., Ocak Z., Ozdemir M., Ocak M., Bekar M., Aksoy M.

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.13, sa.1, ss.49-52, 2003 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Konu: 1
  • Basım Tarihi: 2003
  • Dergi Adı: INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Sayfa Sayıları: ss.49-52

Özet

Seven novel 3-alkyl (aryl)-4-(2-furylmethyleneamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were synthesized in good Yields by the reactions of 3-alkyl (aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) with furan-2-carboxyl aldehyde. The newly synthesized 3 except compound 3c, were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents, including acetonitrile, methyl alcohol, isopropyl alcohol and tert-butyl alcohol. The half neutralization potential values and the corresponding pKa values were determined for all cases. Thus, the effects of solvents and molecular structure upon acidity were investigated. In addition, N-acetyl derivatives of 3 were also prepared. The structures of thirteen new compounds were established by the elemental analysis. IR, H-1 NMR and UV spectral data.