Serum Myeloperoxidase Level Is Associated with Heart-Type Fatty Acid-Binding Protein but Not Troponin T in Patients with Chronic Heart Failure

GEDİKLİ Ö. , Kiris A. , Hosoglu Y. , Karahan C., Kaplan S.

MEDICAL PRINCIPLES AND PRACTICE, vol.24, no.1, pp.42-46, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1159/000368717
  • Page Numbers: pp.42-46


Objective: Our aim was to investigate the possible relationship between myeloperoxidase (MPO) and myocardial damage markers such as heart-type fatty acid-binding protein (H-FABP) and troponin T (TnT) in patients with chronic heart failure (HF). Materials and Methods: Forty-two consecutive patients (age range: 27-80 years) with chronic HF were enrolled in the study. Serum H-FABP, TnT and MPO levels were measured. Routine biochemical and clinical parameters were recorded. Echocardiographic examinations were performed on all patients. A linear regression analysis was performed to determine the correlates of serum H-FABP. Results: The MPO, H-FABP and TnT levels were 255 +/- 227, 60.6 +/- 48.5 and 0.07 +/- 0.15 ng/ml, respectively. In multiple linear regression analysis, age (beta = -0.36, p = 0.006), creatinine level (beta = 0.3, p = 0.024) and serum MPO level (beta = 0.41, p = 0.009) were significant determinants of H-FABP levels. Bivariate predictors were not significantly associated with TnT levels in linear regression analyses. Conclusions: The MPO was significantly associated with serum H-FABP levels but not with TnT. (C) 2014 S. Karger AG, Basel