Comparison of focally induced epileptiform activities in C57BL/6 and BALB/c mice by using in vivo EEG recording

Aydin-Abidin S., Yildirim M., Abidin I., Akca M., CANSU A.

NEUROSCIENCE LETTERS, cilt.504, sa.2, ss.165-169, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 504 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.neulet.2011.09.030
  • Dergi Adı: NEUROSCIENCE LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.165-169
  • Anahtar Kelimeler: Penicillin induced epilepsy, C57BL/6, BALB/c, EEG, Mice, INBRED MOUSE STRAINS, RECEPTOR-IONOPHORE COMPLEX, DIFFERENTIAL SENSITIVITY, SEIZURE SUSCEPTIBILITY, GENETIC INFLUENCES, KAINIC ACID, BRAIN, LOCI, SITE, PENTYLENETETRAZOL
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Epilepsy characterized by repeated seizures is influenced by genetic factors. Seizure response of inbred mouse strains changes depending on the variety of stimuli including chemical (e.g., pentylenetetrazole, nicotine, cocaine, NMDA, kainate), physical (e.g., auditory) or electrical. In this study, we compared the susceptibilities of C57BL/6 and BALB/c mice strains to penicillin induced epileptiform activity (a focally induced, experimental epilepsy model), by analyzing the spike onset latency, spike amplitude and spike frequency. The power spectrums of baseline EEGs were also investigated. We found no alterations of spike onset latencies between the C57 and BALB mice. However, spike amplitudes and spike frequencies were found to be higher in BALB mice than C57 mice. With regard to EEG power spectrum, absolute power of investigated bands was not different between the two strains. Interestingly, the relative power of all investigated bands differed significantly between two strains. The relative power of delta and theta was lower whereas relative power of alpha, beta and gamma was higher in C57 mice compared to BALB mice. In conclusion, our findings showed that BALB mice are more sensitive to penicillin induced epileptiform activity when compared to C57 strain. (C) 2011 Elsevier Ireland Ltd. All rights reserved.