Poly(methyl red), PMR, was electropolymerized on glassy carbon electrodes by potential cycling in 50mM phosphate buffer solution at pH7.0 and 8.0 and Britton Robinson buffer solution in the pH range 7.0-11.0. The electrochemical behavior of PMR modified electrodes was investigated by cyclic voltammetry in Britton Robinson buffer solution at different pHs from 5.0 to 10.0 and found that the best PMR film formation was obtained at pH9.0. Uric acid was quantitatively determined at PMR modified electrodes by cyclic voltammetry and differential pulse voltammetry in Britton Robinson buffer at pH5.0. Both methods presented a linear dependence between the anodic peak current and the concentration of uric acid in the range of 0.4 to 60 M and 0.08 to 100 M with the limits of detection of 0.038 and 0.009 M for cyclic voltammetry and differential pulse voltammetry, respectively. Poly(methyl red) as redox mediator allowed the determination of uric acid without any interferences from the substances in serum samples.