Short-term antibacterial activity and compressive strength of biodentine containing chlorhexidine/cetirimide mixtures

Deveci C., Tuzuner T., Cinar C., Odabas M. E., Buruk C. K.

NIGERIAN JOURNAL OF CLINICAL PRACTICE, vol.22, no.2, pp.227-231, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.4103/njcp.njcp_436_18
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.227-231
  • Keywords: Antimicrobial activity, Biodentine, cetrimide, chlorhexidine, DENTIN SUBSTITUTE, PHYSICAL-PROPERTIES, PRIMARY TEETH, PULP, CEMENTS, FAECALIS, LESIONS
  • Karadeniz Technical University Affiliated: Yes


Background and Purpose: Aim is to evaluate the antibacterial activity and physical properties of Biodentine containing chlorhexidine (CHX)/cetrimide (CT) mixtures at 24 h. Materials and Methods: Powder formulations of CHX (2.5%) and CT (2.5%) were added to the powder of Biodentine and served as experimental groups (EXP). Antibacterial free groups were designed as control (CNT). The antibacterial acitivity (AB) (n = 5; for each) of disc-shaped specimens against Streptococcus mutans and Lactobacillius casei and compressive strength (CS) (n = 10; for each) tests used both for groups after 24 h after polymerization. Statistical Analysis Used: Normality of data were tested with the ShapirouWilk test. Significant differences were analyzed with the MannuWhintey U test for both the methods (agar disk diffusion and compressive strength) at a significance level of P < 0.05. Results: Significantly higher antibacterial effects were obtained in EXP groups compared to the CNTs for both bacteria after 24 h, distinctly (P < 0.01). No differences were found between groups regarding the CS values (P 0.05). Conclusion: Since the incorporation of 5% CHX/CT to the Biodentine exhibited acceptable antibacterial activity without hampering compressive strength values at 24 h, this combination could be a promising alternative for eliminating the residual bacteria for indirect pulp-capping therapies.