THE EFFECTS OF BAY K-8644 ON AGONIST-INDUCED CONTRACTIONS IN GUINEA-PIG URINARY-BLADDER


GACAR N., GACAR H., MOCAN H., UCUNCU Z., OZGUR G., KALYONCU N.

ACTA PHARMACEUTICA JUGOSLAVICA, vol.41, no.3, pp.211-216, 1991 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 3
  • Publication Date: 1991
  • Title of Journal : ACTA PHARMACEUTICA JUGOSLAVICA
  • Page Numbers: pp.211-216

Abstract

In this study the effects of Bay K 8644 a new Ca2+ channel activator, on agonist-induced contractions in guinea-pig urinary bladders were investigated. Histamine and serotonin (10(-9) - 10(-4) M) produced a dose-dependent contraction. Maximum contraction was obtained by 10(-5) M serotonin. Its value was 990.00 mg.