THE EFFECTS OF BAY K-8644 ON AGONIST-INDUCED CONTRACTIONS IN GUINEA-PIG URINARY-BLADDER

GACAR N., GACAR H., MOCAN H., UCUNCU Z., OZGUR G., KALYONCU N. İ.

ACTA PHARMACEUTICA JUGOSLAVICA, cilt.41, sa.3, ss.211-216, 1991 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 3
  • Basım Tarihi: 1991
  • Dergi Adı: ACTA PHARMACEUTICA JUGOSLAVICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.211-216
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

In this study the effects of Bay K 8644 a new Ca2+ channel activator, on agonist-induced contractions in guinea-pig urinary bladders were investigated. Histamine and serotonin (10(-9) - 10(-4) M) produced a dose-dependent contraction. Maximum contraction was obtained by 10(-5) M serotonin. Its value was 990.00 mg.