Synthesis and Antioxidant and Antibacterial Activities of Novel 4-({[3-Alkyl(aryl)-5-oxo-4,5-dihydro-1<i>H</i>-1,2,4-triazol-4-yl]imino}-methyl)phenyl 4-Nitrobenzoate Derivatives

Alkan, M.; Yuksek, H.; Manap, S.; Ozdemir, G.; Beytur, M.; Aytemiz, F.; Sahin, N.; Agirbas, H.; GÜRSOY KOL, ÖZLEM

doi:10.1134/s1070428022120132

Synthesis and Antioxidant and Antibacterial Activities of Novel 4-({[3-Alkyl(aryl)-5-oxo-4,5-dihydro-1<i>H</i>-1,2,4-triazol-4-yl]imino}-methyl)phenyl 4-Nitrobenzoate Derivatives

Alkan M., Yuksek H., Manap S., Ozdemir G., Beytur M., Aytemiz F., ...Daha Fazla

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, cilt.58, sa.12, ss.1839-1850, 2022 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 58 Sayı: 12
Basım Tarihi: 2022
Doi Numarası: 10.1134/s1070428022120132
Dergi Adı: RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Index Chemicus (IC)
Sayfa Sayıları: ss.1839-1850
Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

It is known that acetyl derivatives, Schiff bases, and Mannich bases obtained from 1,2,4-triazol-5-ones have significant antibacterial and antioxidant activities. Herein, 27 new 1,2,4-triazole derivatives were synthesized, and their antioxidant and antibacterial properties were investigated. The metal chelating activity of the synthesized compounds and especially the effect against gram-positive bacteria were found to be significant. The effect against gram-negative strains was also important. Structure determination of the synthesized com-pounds was performed on the basis of their H-1 and C-13 NMR, IR, and high-resolution mass spectra.