Synthesis and Antioxidant and Antibacterial Activities of Novel 4-({[3-Alkyl(aryl)-5-oxo-4,5-dihydro-1<i>H</i>-1,2,4-triazol-4-yl]imino}-methyl)phenyl 4-Nitrobenzoate Derivatives
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, cilt.58, sa.12, ss.1839-1850, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 58 Sayı: 12
- Basım Tarihi: 2022
- Doi Numarası: 10.1134/s1070428022120132
- Dergi Adı: RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Index Chemicus (IC)
- Sayfa Sayıları: ss.1839-1850
- Karadeniz Teknik Üniversitesi Adresli: Hayır
Özet
It is known that acetyl derivatives, Schiff bases, and Mannich bases obtained from 1,2,4-triazol-5-ones have significant antibacterial and antioxidant activities. Herein, 27 new 1,2,4-triazole derivatives were synthesized, and their antioxidant and antibacterial properties were investigated. The metal chelating activity of the synthesized compounds and especially the effect against gram-positive bacteria were found to be significant. The effect against gram-negative strains was also important. Structure determination of the synthesized com-pounds was performed on the basis of their H-1 and C-13 NMR, IR, and high-resolution mass spectra.