Sequence Variant in the LPIN1 gene in Patients with Metabolic Syndrome

KURAL, BİRGÜL; DEĞER, ORHAN; Erem, CİHANGİR; YUCESAN, FULYA; Barlak, Yasam; Turan, Ibrahim; ALİYAZICIOĞLU, REZZAN

doi:10.5505/tjb.2013.41033

Sequence Variant in the LPIN1 gene in Patients with Metabolic Syndrome

KURAL B. V., DEĞER O., Erem C., YUCESAN F., Barlak Y., Turan I., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.38, sa.3, ss.280-285, 2013 (SCI-Expanded, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 38 Sayı: 3
Basım Tarihi: 2013
Doi Numarası: 10.5505/tjb.2013.41033
Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.280-285
Anahtar Kelimeler: metabolic syndrome, LPIN1, lipin-1, INSULIN-RESISTANCE, LIPIN, ASSOCIATION, POLYMORPHISMS, BIOSYNTHESIS, OBESITY, FAMILY, ROLES
Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Objective: Metabolic syndrome (MetS) is a complex disease characterized by insulin resistance, abdominal obesity, hyperglycemia, hypertension, hypertriglyceridemia and low HDL-cholesterol level. The aim of the study was to evaluate the sequence variations in the LPIN1 gene in MetS. This gene codes lipin-1 protein which functions as Mg-dependent phosphatidic phosphatase enzyme and transcriptional coactivator.