Carbonic Anhydrase IX in the Prediction of Right Ventricular Dysfunction in Patients With Hemodynamically Stable Acute Pulmonary Embolism

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Abul Y., Ozsu S. S., MENTEŞE A., DURMUŞ İ., BEKTAS H., PEHLIVANLAR M., ...More

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, vol.20, no.8, pp.838-843, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 8
  • Publication Date: 2014
  • Doi Number: 10.1177/1076029613486540
  • Journal Name: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.838-843
  • Keywords: pulmonary embolism, right ventricular dysfunction, carbonic anhydrase IX, BRAIN NATRIURETIC PEPTIDE, TROPONIN-T ASSAY, PROGNOSTIC VALUE, NORMOTENSIVE PATIENTS, RISK STRATIFICATION, HYPOXIA, ECHOCARDIOGRAPHY, MANAGEMENT, EXPRESSION, DIAGNOSIS
  • Karadeniz Technical University Affiliated: Yes

Abstract

Right ventricular dysfunction (RVD) defined by echocardiography and/or by natriuretic peptides is a well-known predictor of prognosis in patients with pulmonary embolism (PE). This study investigated carbonic anhydrase IX (CA IX) levels for predicting echocardiographic RVD in patients with PE. A total of 150 normotensive patients with PE were included. The levels of CA IX, N-terminal pro-brain-type natriuretic peptide (NT-proBNP), and high-sensitive cardiac troponin T were significantly elevated in patients with PE with RVD on echocardiography. A receiver-operating characteristic curve analysis showed a value of 0.751 for CA IX, 0.714 for NT-proBNP, and 0.650 for high-sensitive troponin-T to predict RVD on echocardiography. The cutoff value to predict RVD was 32.45 pg/mL for CA IX (sensitivity: 89.3% and specificity: 51.1%). There was a significant positive correlation between the CA IX level and the systolic pulmonary arterial pressure on echocardiography ( = .21; P = .035). The CA IX is a significant serologic predictor of RVD in acute PE and correlates with systolic pulmonary arterial pressure.