Synthesis of some 4-(arylmethylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones


Kahveci B. , Bekircan O. , Serdar M. , İkizler A.

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, cilt.42, ss.1527-1530, 2003 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 42 Konu: 6
  • Basım Tarihi: 2003
  • Dergi Adı: INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
  • Sayfa Sayıları: ss.1527-1530

Özet

A series of 3-alkyl-4-(arylmethyleneamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones 2 are obtained and reduced with NaBH4 selectively to afford 3-alkyl-4-(arylmethylamino)-4,5-dihydro-1H-1,2,4-triazol-5 -ones 3: Compounds of type 2 have recently described as a new class of antitumor agent. Thus, 15 new compounds have been synthesized and characterized by elemental analyses, H-1 NMR, IR and UV spectra. Three of these compounds have been screened for their antitumor activities and found weak cytostatic activity in them.