Cord blood oxidative stress markers correlate with umbilical artery pulsatility in fetal growth restriction

GUVEN E. S. G., KARCAALTINCABA D., KANDEMIR O., KIYKAC S., MENTEŞE A.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, cilt.26, sa.6, ss.576-580, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/14767058.2012.745497
  • Dergi Adı: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.576-580
  • Anahtar Kelimeler: Cord blood, intrauterine growth restriction, ischemia-modified albumin, oxidative stress markers, pulsatility index, umbilical artery, ISCHEMIA-MODIFIED ALBUMIN, MYOCARDIAL-ISCHEMIA, DOPPLER, PREGNANCIES, INFANTS, FETUS, PRETERM, FLOW, RETARDATION, EXPRESSION
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Objective: To compare cord blood oxidative stress markers (OSM) between intrauterine small fetuses with high umbilical artery (UA) Doppler indices and normal indices. Methods: Forty women who had oligohydramnios and intrauterine growth-restricted fetuses with abnormal (n = 20, group I) or normal Doppler indices (n = 20, group II) were included. All patients underwent fetal Doppler ultrasound studies. Cord blood was collected at birth and six OSMs (ischemia-modified albumin (IMA), hepatocyte growth factor (HGF), malondialdehyde (MDA)) levels, total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) were studied. Results: The mean cord blood IMA, MDA, TOS, and OSI values for group I were significantly increased when compared to the group II (p < 0.001 for IMA, MDA, TOS, and OSI). However the mean cord blood HGF and TAS values were statistically significantly decreased in group I, compared with group II (p < 0.001 for HGF, and TAS). A significant positive (for IMA, MDA, TOS levels, and OSI ratio) and negative (for HGF and TAS levels) correlations between UA pulsatility index (PI) and cord blood OSM were found. Conclusion: The correlation between cord blood OSM and Doppler blood flow changes shown in this study may contribute to understanding the underlying oxidative stress-related mechanisms.