FK506-binding protein localizations in human penile innervation

Lagoda G., Sezen S. F., Liu T., Hoeke A., Burnett A. L.

BJU INTERNATIONAL, vol.101, no.5, pp.604-609, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 101 Issue: 5
  • Publication Date: 2008
  • Doi Number: 10.1111/j.1464-410x.2007.07290.x
  • Journal Name: BJU INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.604-609
  • Keywords: prostate, penis, FKBP, immunophilin, neurotrophic, nerve, CAVERNOUS NERVE INJURY, DEVELOPMENTAL REGULATION, RADICAL PROSTATECTOMY, CRUSH INJURY, IMMUNOPHILIN, LIGANDS, SYSTEM, FKBP65, FK506, RAT
  • Karadeniz Technical University Affiliated: No

Abstract

To determine if FK506-binding proteins (FKBPs) are localized to the autonomic nerve supply of the human penis because FK506 (an immunosuppressant drug) has been linked to enhanced nerve regeneration after nerve injury and neurodegenerative diseases by binding to FKBPs, a select group of immunophilins.