Akademik Veri Yönetim Sistemi
JOURNAL OF HEALTH SCIENCES, cilt.33, sa.2, ss.190-198, 2024 (Hakemli Dergi)
The research aimed to analyze the volatile compounds by using
SPME-GC-MS and to detect anticholinesterase, antityrosinase,
and antimicrobial potential of metanol extract of Alcea calvertii
Boiss., an endemic species for Türkiye. The inhibitory effects of
tyrosinase, acetyl cholinesterase, and butyrylcholinesterase of
the plant were determined by spectroscopic technique and the
plant’s antimicrobial activity was assessed using the agar diffusion method. A total of 18 volatile compounds were specified
belonging to terpenes classes. o-cymene (10.60%) and sesquicineole (15.55%) were detected as major volatile components of the species by the SPME-GC-MS technique. Meaningful
antimicrobial activity was observed on Candida tropicalis, Enterococcus faecalis, Escherichia coli, Mycobacterium smegmatis,
Staphylococcus aureus, and Pseudomonas aeruginosa. The half
maximal inhibitory concentration (IC50) value of the plant was
determined 60.12 ± 1.75 μg/mL as a result of tyrosinase assay.
IC50 value was found 111.54 ± 1.75 μg/mL, according to butyrylcholinesterase inhibition studies. Considering all the findings, it has been determined that the plant includes diverse
volatile compounds and showed promising antimicrobial, tyrosinase inhibitory, and moderate butyrylcholinesterase inhibitory effects so Alcea calvertii may be the up-and-coming
source of natural medicine for microbial and dermatological
diseases although limited to its effects for Alzheimer's disease.