The unconfined compressive strength (UCS) of intact rocks is an important geotechnical parameter for engineering applications. Determining UCS using standard laboratory tests is a difficult, expensive and time consuming task. This is particularly true for thinly bedded, highly fractured, foliated, highly porous and weak rocks. Consequently, prediction models become an attractive alternative for engineering geologists. The objective of study is to select the explanatory variables (predictors) from a subset of mineralogical and index properties of the samples, based on all possible regression technique, and to prepare a prediction model of UCS using artificial neural networks (ANN). As a result of all possible regression, the total porosity and P-wave velocity in the solid part of the sample were determined as the inputs for the Levenberg-Marquardt algorithm based ANN (LM-ANN). The performance of the LM-ANN model was compared with the multiple linear regression (REG) model. When training and testing results of the outputs of the LM-ANN and REG models were examined in terms of the favorite statistical criteria, which are the determination coefficient, adjusted determination coefficient, root mean square error and variance account factor, the results of LM-ANN model were more accurate. In addition to these statistical criteria, the non-parametric Mann-Whitney U test, as an alternative to the Student's t test, was used for comparing the homogeneities of predicted values. When all the statistics had been investigated, it was seen that the LM-ANN that has been developed, was a successful tool which was capable of UCS prediction.