Liver involvement in children with Familial Mediterranean fever

Unal F., ÇAKIR M., Baran M., Arikan C., Yuksekkaya H. A., AYDOĞDU S.

DIGESTIVE AND LIVER DISEASE, vol.44, no.8, pp.689-693, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 8
  • Publication Date: 2012
  • Doi Number: 10.1016/j.dld.2012.01.003
  • Journal Name: DIGESTIVE AND LIVER DISEASE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.689-693
  • Karadeniz Technical University Affiliated: Yes

Abstract

Aim: Familial Mediterranean fever is characterised by recurrent, febrile, inflammatory attacks of the serosal membranes. Prolonged inflammatory response is triggered secondary to cytokine stimulation due to reduced activity of pyrin. Inflammatory cytokines play major role in the pathogenesis of acute liver injury; and chronic, recurrent cytokine production may cause chronic hepatitis/cirrhosis. We aimed to analyse liver involvement in children with Familial Mediterranean fever.