New Schiff Bases with Thiophene Ring: Synthesis, Biological Activities, and Molecular Docking Study

Çelik F., Inan Bektaş K., Güler H. İ., Direkel Ş., Ünver Y.

RUSSIAN JOURNAL OF GENERAL CHEMISTRY, cilt.93, sa.2, ss.409-417, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 93 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1134/s107036322302024x
  • Dergi Adı: RUSSIAN JOURNAL OF GENERAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Index Chemicus (IC)
  • Sayfa Sayıları: ss.409-417
  • Anahtar Kelimeler: Schiff bases, thiophene, leishmanicidal activity, antimicrobial activity, molecular docking study, DERIVATIVES, ANTIOXIDANT, DFT
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

In this study, the synthesis of Schiff bases containing substituted thiophene was carried out. The compounds were characterized by Fourier transform infrared (FTIR), H-1 and C-13 NMR spectroscopy methods. In the study, it was aimed to determine in vitro leishmanicidal activities of five different newly synthesized compounds against standard L. infantum promastigotes by microdilution method. In silico analysis was used to examine the probable interactions between the synthesized compound and the target proteins.