Synthesis and bio-molecular study of (+)-N-Acetyl-a-amino acid dehydroabietylamine derivative for the selective therapy of hepatocellular carcinoma

MUSTUFA, GÖKHAN; Ozen, Cigdem; HASHMI, Imran; ASLAM, Afshan; BAIG, Jameel; Yildiz, Gokhan; MUHAMMAD, Shoaib; SOLANGI, Imam; NAQVI, Naim; Ozturk, Mehmet; ALI, Firdous

doi:10.1186/s12885-016-2942-5

Synthesis and bio-molecular study of (+)-N-Acetyl-a-amino acid dehydroabietylamine derivative for the selective therapy of hepatocellular carcinoma

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MUSTUFA M. A., Ozen C., HASHMI I. A., ASLAM A., BAIG J. A., Yildiz G., ...More

BMC CANCER, vol.16, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 16
Publication Date: 2016
Doi Number: 10.1186/s12885-016-2942-5
Journal Name: BMC CANCER
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Karadeniz Technical University Affiliated: No

Abstract

Background: The purpose of present work is to synthesize novel (+)-Dehydroabietylamine derivatives (DAAD) using N-acetyl-a-amino acid conjugates and determine its cytotoxic effects on hepatocellular carcinoma cells.