The ultimate lateral resistance of face-to-face joints connected with two rows of 16-gauge coated staples in three oriented strandboards (OSB) of different densities was investigated. Experimental results indicated that the ultimate lateral resistance of the face-to-face OSB joints increases significantly as the number of staples increases from two to eight in increments of two. Vertical and horizontal staple alignment was found to have no significant effect on the ultimate lateral resistance of the face-to-face OSB joints when the number of staples used was less than eight. The face-to-face OSB joints constructed of a higher density material yielded a higher ultimate lateral resistance, but the significant increase in ultimate lateral resistances due to increase in material density depended on the number of staples used and also staple alignment. The increase in the ultimate lateral resistance became more sensitive to material density increase once the number of staples used was six and higher. The ultimate lateral resistance of face-to-face OSB joints connected with two rows of 16-gauge coated staples can be reasonably estimated using two alternative empirical power equations. One equation requires the ultimate lateral resistance of a face-to-face OSB joint connected with one staple. The other equation requires the density of an OSB material used as the joint main member.