Presence and characterization of prostaglandin D2-related molecules in nasal mucosa of patients with allergic rhinitis

OKANO, Mitsuhiro; FUJIWARA, Tazuko; SUGATA, Yuji; GOTOH, Daisuke; MASAOKA, Yoshihisa; SOGO, Masahiro; TANIMOTO, Wakana; YAMAMOTO, Miki; MATSUMOTO, Rie; EGUCHI, Naomi; KINIWA, Mamoru; Isik, ABDÜLCEMAL; URADE, Yoshihiro; NISHIZAKI, Kazunori

doi:10.2500/ajr.2006.20.2865

Presence and characterization of prostaglandin D2-related molecules in nasal mucosa of patients with allergic rhinitis

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OKANO M., FUJIWARA T., SUGATA Y., GOTOH D., MASAOKA Y., SOGO M., ...More

AMERICAN JOURNAL OF RHINOLOGY, vol.20, no.3, pp.342-348, 2006 (SCI-Expanded)

Publication Type: Article / Article
Volume: 20 Issue: 3
Publication Date: 2006
Doi Number: 10.2500/ajr.2006.20.2865
Journal Name: AMERICAN JOURNAL OF RHINOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.342-348
Karadeniz Technical University Affiliated: Yes

Abstract

Background: Prostaglandin D2 (PGD2) is the major prostanoid produced in the acute phase of allergic reactions. However, its pathophysiological role in addition to the pathway of production in allergic rhinitis remains unclear. We sought to determine the expression of synthases and receptors for PGD2 in human nasal mucosa. These expressions were compared between allergic and nonallergic patients.