Presence and characterization of prostaglandin D2-related molecules in nasal mucosa of patients with allergic rhinitis


OKANO M., FUJIWARA T., SUGATA Y., GOTOH D., MASAOKA Y., SOGO M., ...More

AMERICAN JOURNAL OF RHINOLOGY, vol.20, no.3, pp.342-348, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 3
  • Publication Date: 2006
  • Doi Number: 10.2500/ajr.2006.20.2865
  • Title of Journal : AMERICAN JOURNAL OF RHINOLOGY
  • Page Numbers: pp.342-348

Abstract

Background: Prostaglandin D2 (PGD2) is the major prostanoid produced in the acute phase of allergic reactions. However, its pathophysiological role in addition to the pathway of production in allergic rhinitis remains unclear. We sought to determine the expression of synthases and receptors for PGD2 in human nasal mucosa. These expressions were compared between allergic and nonallergic patients.