The effect of combined treatment of alpha-tocopherol, ascorbic acid, and pyridoxine with NMDA blocker memantine on penicillin-induced epileptiform activity in rats

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Aydin D., Yildirim M., Ayyildiz M., Agar E.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.43, no.2, pp.245-250, 2013 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 43 Issue: 2
• Publication Date: 2013
• Doi Number: 10.3906/sag-1204-7
• Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.245-250
• Karadeniz Technical University Affiliated: Yes

Abstract

Aim: To evaluate the effects of coadministration of vitamins alpha-tocopherol, ascorbic acid, and pyridoxine with memantine on a penicillin-induced experimental epilepsy model in rats so as to clarify the eventual interaction between these vitamins and the N-methyl-D-aspartate (NMDA) system.