Ecofriendly Solventless Synthesis and Reduction Reaction of Some Triazole Compounds and Evaluation of Their Antimicrobial Activity

Özil M., Menteşe E., Karaoğlu S. A., KAHVECİ B.

SYNTHETIC COMMUNICATIONS, cilt.43, sa.9, ss.1328-1336, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 9
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1080/00397911.2011.632831
  • Dergi Adı: SYNTHETIC COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1328-1336
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

A number of triazole-3-one compounds have been synthesized, and reduction of the carbonyl group in the molecule has been carried out to give a corresponding hydroxyl group that possesses asymmetric carbon atom in good yields and short reaction times. It is ecofriendly because it is produced by straightforward microwave irradiation in the absence of solvent. All newly synthesized compounds were also screened for their antimicrobial activities. The antimicrobial activity study revealed that 2d, 2i, 3c, and 3g-j showed good activity against a variety of microorganisms. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.