Protective effects of L-theanine against doxorubicin-induced nephrotoxicity in rats

Altinkaynak Y., KURAL B., Akcan B. A., Bodur A., ÖZER YAMAN S., YULUĞ E., ...Daha Fazla

BIOMEDICINE & PHARMACOTHERAPY, cilt.108, ss.1524-1534, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 108
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.biopha.2018.09.171
  • Dergi Adı: BIOMEDICINE & PHARMACOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1524-1534
  • Anahtar Kelimeler: Antioxidant, Apoptosis, Glutathione, Inflammation, L-Theanine, CISPLATIN-INDUCED NEPHROTOXICITY, GAMMA-GLUTAMYL-TRANSPEPTIDASE, ACUTE KIDNEY INJURY, UNIQUE AMINO-ACID, OXIDATIVE STRESS, INDUCED NEUROTOXICITY, UP-REGULATION, LIVER-INJURY, GLUTATHIONE, METABOLISM
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background/aim: L-theanine is the unique amino acid found in tea plants, has antioxidant and antiinflammatory activities, and functions in mental concentration and sleep quality. In this study, it is aimed to investigate the effects of L-theanine on doxorubicin (DOX, a chemotherapeutic agent) induced nephrotoxicity in rats, especially via GSH related enzymes.