The inhibitory effect of trimetazidine on detrusor contractility - a potential repositioning of trimetazidine for the treatment of overactive bladder.
The Journal of pharmacy and pharmacology, cilt.74, sa.1, ss.94-102, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 74 Sayı: 1
- Basım Tarihi: 2022
- Doi Numarası: 10.1093/jpp/rgab072
- Dergi Adı: The Journal of pharmacy and pharmacology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.94-102
- Anahtar Kelimeler: calcium, detrusor, ion channels, isolated tissue bath, fura-2, trimetazidine, ION-CHANNEL GENE, NITRIC-OXIDE, SMOOTH-MUSCLE, CA2+ INFLUX, RELAXATION, PATHOPHYSIOLOGY, PHYSIOLOGY, ENTRY, PIG
- Karadeniz Teknik Üniversitesi Adresli: Evet
Özet
Objectives This study aimed to identify the effect of trimetazidine (TMZ), an antianginal drug, on detrusor smooth muscle (DSM) contractility and its possible mechanisms of action.