The inhibitory effect of trimetazidine on detrusor contractility - a potential repositioning of trimetazidine for the treatment of overactive bladder.


Engin S., Kaya Yasar Y., Barut E. N., Getboga D., Erac Y., Sezen S. F.

The Journal of pharmacy and pharmacology, vol.74, no.1, pp.94-102, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 74 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.1093/jpp/rgab072
  • Journal Name: The Journal of pharmacy and pharmacology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.94-102
  • Keywords: calcium, detrusor, ion channels, isolated tissue bath, fura-2, trimetazidine, ION-CHANNEL GENE, NITRIC-OXIDE, SMOOTH-MUSCLE, CA2+ INFLUX, RELAXATION, PATHOPHYSIOLOGY, PHYSIOLOGY, ENTRY, PIG
  • Karadeniz Technical University Affiliated: Yes

Abstract

Objectives This study aimed to identify the effect of trimetazidine (TMZ), an antianginal drug, on detrusor smooth muscle (DSM) contractility and its possible mechanisms of action.