The inhibitory effect of trimetazidine on detrusor contractility - a potential repositioning of trimetazidine for the treatment of overactive bladder.

Engin S., Kaya Yasar Y., Barut E. N., Getboga D., Erac Y., Sezen S. F.

The Journal of pharmacy and pharmacology, cilt.74, sa.1, ss.94-102, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 74 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1093/jpp/rgab072
  • Dergi Adı: The Journal of pharmacy and pharmacology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.94-102
  • Anahtar Kelimeler: calcium, detrusor, ion channels, isolated tissue bath, fura-2, trimetazidine, ION-CHANNEL GENE, NITRIC-OXIDE, SMOOTH-MUSCLE, CA2+ INFLUX, RELAXATION, PATHOPHYSIOLOGY, PHYSIOLOGY, ENTRY, PIG
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Objectives This study aimed to identify the effect of trimetazidine (TMZ), an antianginal drug, on detrusor smooth muscle (DSM) contractility and its possible mechanisms of action.