Synthesis, Antibacterial, Antiurease, and Antioxidant Activities of Some New 1,2,4-Triazole Schiff Base and Amine Derivatives

Sokmen B. B., Gumrukcuoglu N., Ugras S., Sahin H., Sagkal Y., Ugras H. I.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, vol.175, no.2, pp.705-714, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 175 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1007/s12010-014-1307-2
  • Journal Name: APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.705-714
  • Keywords: Acyl hydrazone, 1,2,4-triazole, Schiff base, Reduction, Urease inhibition activity, Antioxidant activity, BIS-1,2,4-TRIAZOLE DERIVATIVES, ANTIMICROBIAL ACTIVITIES, UREASE, ANTIELASTASE, BACTERIA, AMMONIA, AGENTS
  • Karadeniz Technical University Affiliated: Yes

Abstract

The acylhydrazone compound named ethyl N'-furan-2-carbonylbenzohydrazonate was synthesized by the condensation of ethyl benzimidate hydrochloride with furan-2-carbohydrazide. The treatment of the acylhydrazone with hydrazine hydrate afforded 4-amino-3-furan-2-yl-5-phenyl-1,2,4-triazole. The usage of this compound with various aromatic aldehydes resulted in the formation of 4-arylidenamino-3-furan-2-yl-5-phenyl-1,2,4-triazoles. Sodium borohydride reduction of 4-arylidenamino derivatives afforded 4-alkylamino-3-furan-2-yl-5-phenyl-1,2,4-triazoles. The obtained products were identified by FT-IR, H-1-NMR, C-13-NMR. A series of compounds were evaluated for their antibacterial, antiurease, and antioxidant activities. The results showed that the synthesized new compounds had effective antiurease and antioxidant activities.