Atıf İçin Kopyala
Erkut M., Özkaya E., Fidan S., Coşar A. M.
JOURNAL OF CONTEMPORARY MEDICINE, cilt.14, sa.1, ss.1-8, 2024 (Hakemli Dergi)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
14
Sayı:
1
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Basım Tarihi:
2024
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Doi Numarası:
10.16899/jcm.1362566
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Dergi Adı:
JOURNAL OF CONTEMPORARY MEDICINE
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Derginin Tarandığı İndeksler:
Directory of Open Access Journals
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Sayfa Sayıları:
ss.1-8
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Karadeniz Teknik Üniversitesi Adresli:
Evet
Özet
Aim: We aimed to investigate the relationship between the presence of complications at the time of diagnosis or during follow-up and fecal calprotectin in patients with inflammatory bowel disease.
Materials and Methods: Fecal calprotectin level was studied by the chromatographic lateral flow immunoassay method.
Results: A total of 76 patients, 26 (34%) with Crohn's disease and 50 (66%) with ulcerative colitis, were included in the study. At the time of diagnosis and during follow-up, complications were observed in 17 (22%) and 20 (26%) patients, respectively. At the time of diagnosis, fecal calprotectin level was low (<50 mg/kg) in 26 (34%) patients, borderline (50-100 mg/kg) in 16 (21%) patients, and high (>100 mg/kg) in 34 (45%) patients. Hemoglobin and albumin levels were lower (p=0.013, p=0.012, respectively), and platelet count, eryrocyte sedimentation rate, and C-reactive protein levels were higher (p<0.001, p=0.004, p<0.001, respectively) in patients with high fecal calprotectin level than patients with low fecal calprotectin level. At the time of diagnosis and during follow-up, complications were higher in patients with high fecal calprotectin level than patients with low and borderline fecal calprotectin levels (p=0.001). The risk of developing complications was found to be 26 times higher at the time of diagnosis in patients with fecal calprotectin level >100 µg/g than patients with fecal calprotectin level below this value and 8 times higher during follow-up (p=0.006, p=0.015, respectively).
Conclusion: The use of fecal calprotectin level together with tests showing acute inflammation in inflammatory bowel disease may predict the development of complications.