A preliminary study on the genotoxic effects of aqueous extracts of Tanacetum parthenium (Asteraceae) on the Helianthus annuus root tip cells

Sağan R., İnceer H.

III INTERNATIONAL BIOLOGY CONGRESS, Bishkek, Kırgızistan, 23 - 25 Nisan 2026, ss.1-2, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Bishkek
  • Basıldığı Ülke: Kırgızistan
  • Sayfa Sayıları: ss.1-2
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Backround: Medicinal plants are organisms that have long been used in traditional medicine and possess a wide range of pharmacological effects due to their bioactive compounds. However, investigating their genotoxic potential is of great importance for the safe use of these plants. Tanacetum parthenium (L.) Sch.Bip., a perennial herb belonging to the Asteraceae family, is widely used for various health issues such as migraine, fever, headache, and gallstones. Although the genotoxic effects of T. parthenium on animal cell lines are well-documented, no genotoxicity studies have been conducted on plant genetic systems.

Aims: In this study, for the first time, the genotoxic effects of aqueous extracts prepared from parts of T. parthenium collected during the flowering period were investigated on Helianthus annuus L. (sunflower) root tip cells.

Materials and methods: Germinated sunflower seeds were treated with extracts at concentrations of 2.5, 5, 10, 20, and 40 mg/mL of T. parthenium for 24 hours. In each treatment, at least 500 cells were analyzed from 5 preparations, and the mitotic index was calculated.

Results: The results of the study showed that the mitotic index decreased by 38.52% compared to the control group. The findings indicate that T. parthenium extracts cause a mitotic-depressive effect in mitotic cells in a consantration-dependent manner.

Conclusion: The study demonstrates that T. parthenium exhibits significant genotoxic effects in root tip cells of H. annuus and highlights the need for more comprehensive studies to ensure the safe use of the plant.

Keywords: Helianthus annuus, T. parthenium, Genotoxicity, Mitotic Index