Synthesis, Antioxidant and Some Enzyme Inhibition Activities of New Sulfonyl Hydrazones and their Molecular Docking Simulations

Aktar B. S. K., Sicak Y., TATAR YILMAZ G., Oruc-Emre E. E.

PHARMACEUTICAL CHEMISTRY JOURNAL, cilt.56, sa.4, ss.559-569, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s11094-022-02674-3
  • Dergi Adı: PHARMACEUTICAL CHEMISTRY JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE
  • Sayfa Sayıları: ss.559-569
  • Anahtar Kelimeler: sulfonyl hydrazine, antioxidant, anticholinesterase, tyrosinase, urease, molecular docking, ALZHEIMERS-DISEASE, ACETYLCHOLINESTERASE, CHALCONES, BINDING
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

In this work, a series of new sulfonyl hydrazones were synthesized and screened for antioxidant and anticholinesterase, tyrosinase and urease enzyme inhibition activities. In addition, molecular docking study was applied to better understand the inhibitory mechanism at the molecular level. Further, bioavailability of the synthesized compounds is considered in terms of the Lipinski rule and the design of their pharmacokinetic and pharmacodynamic properties is found reliable. In the AChE activity assay results, compound 8 was the most active one, while being less active than galantamine that was used as the standard drug. In the BChE activity testing of sulfonyl hydrazone derivatives (1-8), , compounds 3, 4, 5, 6, 7 and 8 were the most active drugs and showed much better activity than galantamine used as the standard. Compounds 8, 5 and 4 showed the best tyrosinase inhibitory activity with IC50 values of 9.75 +/- 0.23, 13.18 +/- 0.67 and 16.29 +/- 0.73 mM, respectively.