A comparison of imipenem monotherapy versus cefoperazone/sulbactam plus amikacin combination treatment in febrile neutropenic cancer patients

Dincol D., Arican A., Aydin F., Samur M., Willke A., Akbulut H., ...More

CANCER JOURNAL - FRANCE, vol.11, no.2, pp.89-93, 1998 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 2
  • Publication Date: 1998
  • Journal Name: CANCER JOURNAL - FRANCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.89-93
  • Karadeniz Technical University Affiliated: No

Abstract

Background - Empirical antibiotic therapy with a third-generation cephalosporin or a beta-lactam antibiotic which has broad antibacterial spectrum has been standard treatment in cancer patients with neutropenic fever. This prospective randomized trial was carried out to compare the efficacy of monotherapy (imipenem) with combination therapy (cefoperazone/sulbactam plus amikacin) in the empirical treatment of febrile neutropenia,