NEW PYRIDINE DERIVATIVES AS ANTIUREASE INHIBITORS: SYNTHESIS AND THEIR EVALUATION FOR ANTIMICROBIAL ACTIVITIES

Bektas H., Albay C., MENTESE E., DEMİRBAŞ N.

REVUE ROUMAINE DE CHIMIE, vol.62, no.3, pp.199-205, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 3
  • Publication Date: 2017
  • Journal Name: REVUE ROUMAINE DE CHIMIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.199-205
  • Karadeniz Technical University Affiliated: Yes

Abstract

6-Morpholin-4-ylpyridin-3-amine (3) gathered starting from morpholine by two steps was converted into the corresponding arylidenehydrazides through the reaction with several aromatic aldehydes. The treatment of compound 3 with phenylisothiocyanate generated N-(6-morpholin-4-ylpyridin-3-y1)-N-phenylthiourea (6). The synthesis of 1,3-thiazolidine (7) and 1,3-thiazole derivatives was performed from the reaction of 6 with 4-chlorophenacyl bromide and ethyl bromoacetate, respectively. All synthesized compounds were inspected for their antimicrobial and antiurease activites.

6-Morpholin-4-ylpyridin-3-amine (3) gathered starting from morpholine by two steps was converted into the corresponding arylidenehydrazides through the reaction with several aromatic aldehydes. The treatment of compound 3 with phenylisothiocyanate generated N-(6-morpholin-4-ylpyridin-3-y1)-N-phenylthiourea (6). The synthesis of 1,3-thiazolidine (7) and 1,3-thiazole derivatives was performed from the reaction of 6 with 4-chlorophenacyl bromide and ethyl bromoacetate, respectively. All synthesized compounds were inspected for their antimicrobial and antiurease activites.