Using Salivary Nitrite and Nitrate Levels as a Biomarker for Drug-Induced Gingival Overgrowth


Şüküroğlu E. , Güncü G. N. , Kilinc K., Çağlayan F.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, vol.5, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 5
  • Publication Date: 2015
  • Doi Number: 10.3389/fcimb.2015.00087
  • Title of Journal : FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

Abstract

Aim: Drug-induced gingival overgrowth has a multifactorial nature and the pathogenesis is still uncertain. It has been suggested that Nitric Oxide (NO) might play a role in the pathogenesis of drug induced gingival overgrowth due to the contribution of NO to immune response and matrix degradation. NO levels in biological fluids have been used as a diagnostic biomarker in many diseases. The aim of this study is to determine whether NO levels in plasma, saliva, and gingival crevicular fluid (GCF) can serve as a potential biomarker for the evaluation of drug induced gingival overgrowth risk.