Using Salivary Nitrite and Nitrate Levels as a Biomarker for Drug-Induced Gingival Overgrowth

Şüküroğlu, ERKAN; Güncü, Güliz; Kilinc, Kamer; Çağlayan, Feriha

doi:10.3389/fcimb.2015.00087

Using Salivary Nitrite and Nitrate Levels as a Biomarker for Drug-Induced Gingival Overgrowth

Atıf İçin Kopyala

Şüküroğlu E., Güncü G. N., Kilinc K., Çağlayan F.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, cilt.5, 2015 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 5
Basım Tarihi: 2015
Doi Numarası: 10.3389/fcimb.2015.00087
Dergi Adı: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Aim: Drug-induced gingival overgrowth has a multifactorial nature and the pathogenesis is still uncertain. It has been suggested that Nitric Oxide (NO) might play a role in the pathogenesis of drug induced gingival overgrowth due to the contribution of NO to immune response and matrix degradation. NO levels in biological fluids have been used as a diagnostic biomarker in many diseases. The aim of this study is to determine whether NO levels in plasma, saliva, and gingival crevicular fluid (GCF) can serve as a potential biomarker for the evaluation of drug induced gingival overgrowth risk.