Using Salivary Nitrite and Nitrate Levels as a Biomarker for Drug-Induced Gingival Overgrowth
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, vol.5, 2015 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 5
- Publication Date: 2015
- Doi Number: 10.3389/fcimb.2015.00087
- Journal Name: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Karadeniz Technical University Affiliated: Yes
Abstract
Aim: Drug-induced gingival overgrowth has a multifactorial nature and the pathogenesis is still uncertain. It has been suggested that Nitric Oxide (NO) might play a role in the pathogenesis of drug induced gingival overgrowth due to the contribution of NO to immune response and matrix degradation. NO levels in biological fluids have been used as a diagnostic biomarker in many diseases. The aim of this study is to determine whether NO levels in plasma, saliva, and gingival crevicular fluid (GCF) can serve as a potential biomarker for the evaluation of drug induced gingival overgrowth risk.