LETTERS IN DRUG DESIGN & DISCOVERY, vol.16, no.3, pp.313-321, 2019 (Peer-Reviewed Journal)
Article / Article
LETTERS IN DRUG DESIGN & DISCOVERY
Science Citation Index Expanded, Scopus
4(3H)-Quinazolinones, structure elucidation, LasR protein, Pseudomonas aeruginosa, quorum sensing, biofilm formation, QUORUM-SENSING INHIBITORS, PSEUDOMONAS-AERUGINOSA, SWARMING MOTILITY, ACCURATE DOCKING, VIRULENCE, LIGAND, GLIDE, DERIVATIVES, PROTEIN
Background: Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic infections in immunocompromised patients. The inhibition of Quorum Sensing (QS) system has been recognized as an attractive strategy for the treatment of P. aeruginosa infections. In the present study, a series of novel 2-methyl-3[4-(substituedaminosulfonyl)phenyl]-4(3H)-quinazolinones (1-8) were synthesized and tested for their biofilm formation and swarming motility inhibitory activities in P. aeruginosa PA01.