Synthesis, Structure Elucidation and Biological Activities of Some Novel 4(3H)-Quinazolinones as Anti-Biofilm Agents

Turk S., KARAKUŞ S., Ece A., ULUSOY S., Bosgelmez-Tinaz G.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.16, sa.3, ss.313-321, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1570180815666180621101123
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.313-321
  • Anahtar Kelimeler: 4(3H)-Quinazolinones, structure elucidation, LasR protein, Pseudomonas aeruginosa, quorum sensing, biofilm formation, QUORUM-SENSING INHIBITORS, PSEUDOMONAS-AERUGINOSA, SWARMING MOTILITY, ACCURATE DOCKING, VIRULENCE, LIGAND, GLIDE, DERIVATIVES, PROTEIN
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Background: Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic infections in immunocompromised patients. The inhibition of Quorum Sensing (QS) system has been recognized as an attractive strategy for the treatment of P. aeruginosa infections. In the present study, a series of novel 2-methyl-3[4-(substituedaminosulfonyl)phenyl]-4(3H)-quinazolinones (1-8) were synthesized and tested for their biofilm formation and swarming motility inhibitory activities in P. aeruginosa PA01.