Synthesis of Some Novel 1,2,4-Triazol-3-one Derivatives Bearing the Salicyl Moiety and Their Anticonvulsant Activities

KAHVECİ B., Mentese E., Akkaya E., Yilmaz F., DOĞAN İ. S., ÖZEL A.

ARCHIV DER PHARMAZIE, vol.347, no.6, pp.449-455, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 347 Issue: 6
  • Publication Date: 2014
  • Doi Number: 10.1002/ardp.201300427
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.449-455
  • Keywords: Anticonvulsant activity, Microwave irradiation, Salicyl aldehyde, Triazol-3-one, MICROWAVE-ASSISTED SYNTHESIS, ANTIFUNGAL ACTIVITY, TOXICITY
  • Karadeniz Technical University Affiliated: Yes

Abstract

A series of new 1,2,4-triazole-3-one derivatives bearing the salicyl moiety were synthesized by using microwave irradiation, and their chemical structures were identified by IR, H-1 NMR, C-13 NMR, elemental analysis, and LC-MS. The anticonvulsant activities of the compounds 4a-c, 4e, and 5a-e were evaluated by the Anticonvulsant Screening Program of the National Institute of Health, USA. The compounds had moderate anticonvulsant activities in the maximum electroshock-induced seizure and minimal clonic seizure models in mice, without any neurotoxic effects.