A perspective on muscle phenotyping in musculoskeletal research

Foessl I., Ackert-Bicknell C. L., Kague E., Laskou F., Jakob F., Karasik D., ...More

TRENDS IN ENDOCRINOLOGY AND METABOLISM, vol.35, no.6, pp.478-489, 2024 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 6
  • Publication Date: 2024
  • Doi Number: 10.1016/j.tem.2024.01.004
  • Journal Name: TRENDS IN ENDOCRINOLOGY AND METABOLISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, Chemical Abstracts Core, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.478-489
  • Karadeniz Technical University Affiliated: Yes

Abstract

Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term 'osteosarcopenia', is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action 'Genomics of MusculoSkeletal acterization was highlighted as being important, but currently underrecognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.