Synthesis, molecular docking and biological evaluation of some benzimidazole derivatives as potent pancreatic lipase inhibitors

Menteşe E., Yilmaz F., EMIRIK M., Ülker S., KAHVECİ B.

BIOORGANIC CHEMISTRY, cilt.76, ss.478-486, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 76
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.bioorg.2017.12.023
  • Dergi Adı: BIOORGANIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.478-486
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

In this study, a new series of benzimidazole and bisbenzimidazole derivatives were prepared via the reaction of iminoester hydrochlorides and o-phenylenediamines and then screened for their lipase inhibition properties. Among the synthesized molecules, compounds 7a, 8a and 8c showed the best inhibitory effect against lipase enzyme with IC50 values of 1.72 +/- 0.12 mu M, 1.92 +/- 0.28 and 0.98 +/- 0.07 mu M, respectively. Moreover, molecular modeling studies were performed in order to understand to the inhibitory activity of the molecules. Binding poses of the studied compounds were determined at the target sites using induced fit docking (IFD) algorithms. (C) 2017 Elsevier Inc. All rights reserved.