Synthesis of Novel Antipyrine Derivatives Possessing Remarkable Antimicrobial Activities

BAYRAK H., CEBECI Y. U., KARAOGLU S. A.

CHEMISTRYSELECT, cilt.4, sa.44, ss.12906-12908, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 44
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1002/slct.201902376
  • Dergi Adı: CHEMISTRYSELECT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.12906-12908
  • Anahtar Kelimeler: Antimicrobial activity, antipyrine, mannich bases, oxazole, thiazole, triazole, ANTIBACTERIAL
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

In this study, new triazole, thiazole, oxazole and Mannich bases were synthesized starting from antipyrine. All the newly synthesized compounds were screened for their antimicrobial activities against some test microorganisms and among them most of them show very good antituberculosis activity beside gram positive and gram negative bacteria. The structures of all synthesized compounds were determined by spectroscopic methods such as FT-IR, H-1 NMR and C-13 NMR.