This study aims to evaluate the stress values, created in peri-implant region as a consequence of loading on fixed hybrid dentures that was planned with different implant numbers, lengths, or tilting angulations. Thirteen three-dimensional (3D) finite element analysis models were generated with four, five, or seven implants (group A, B, and C). Except the distal implants, all implants were modeled at 4.1 mm (diameter) and 11.5 mm (length) in size. Distal implants were configured to be in five different lengths (6, 8, 11.5, 13, and 16 mm) and three different implant inclination degrees (0A degrees, 30A degrees, and 45A degrees). A 150-N load was applied vertically on prosthesis. Released stresses were evaluated comparatively. The lowest von Mises stress values were found in group C, in the 11.5-mm implant model. Tilting the distal implants 30A degrees caused higher stress values. In 45A degrees-tilting implant models, lower stress values were recorded according to the 30A degrees-tilting models. The ideal implant number is seven for an edentulous maxilla. Tilting the implants causes higher stress values. A 45A degrees inclination of implant causes lower stress values according to the 30A degrees models due to a shorter cantilever. The ideal implant length is 11.5 mm.