Synthesis of some 4,5-dihydro-1H-1,2,4-triazolo-5-ones

YUKSEK H., Bahceci S., OCAK Z., ALKAN M. Z., ERMIS B., MUTLU T., ...Daha Fazla

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.13, sa.4, ss.369-372, 2004 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 4
  • Basım Tarihi: 2004
  • Dergi Adı: INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.369-372
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

3-Alkyl(aryl)-4-amino4,5-dihydro-1H-1,2,4-triazol-5-ones (2) reacted with 4-methoxybenzaldehyde to afford the corresponding 3-alkyl (aryl)-4-(4-methoxybenzylideneamino)-4,5 dihydro-1H-1,2,4-triazol-5-ones (3). The newly synthesized 3 were titrated potentiometrically with tetrabutylammonium hydroxide in four nonaqueous solvents such as methyl alcohol, isopropyl alcohol, tert-butyl alcohol and N,N-dimethylformamide. The half-neutralization potential values and the corresponding pKa values were determined for all compounds synthesized in the solvents described above. Thus, the effects of solvents and molecular structure upon acidity were investigated. In addition, N-acetyl derivatives of 3 were also prepared. Fourteen new synthesized compounds in the study were fully characterized.