N-acetylcysteine amid reduces pancreatic damage in a rat model of acute necrotizing pancreatitis

TÜRKYILMAZ S., Usta A., ÇEKİÇ A. B., Alhan E., Kural B. V., Ercin C.

JOURNAL OF SURGICAL RESEARCH, cilt.203, sa.2, ss.383-389, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 203 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.jss.2016.03.004
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.383-389
  • Anahtar Kelimeler: NACA, N-acetylcysteine amid, Acute necrotizing pancreatitis, THIOL ANTIOXIDANT, OXIDATIVE STRESS, EPITHELIAL-CELLS, ACINAR-CELLS, PATHOPHYSIOLOGY, MECHANISMS, MEDIATORS, APOPTOSIS, PROTECTS, INJURY
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background: Inflammatory explosion and oxidative stress are important mechanisms of injury in acute necrotizing pancreatitis (ANP). This study investigated the effects of N-acetylcysteine amid (NACA), a novel cell-permeant antioxidant with anti-inflammatory activity, on experimental ANP in rats.