N-acetylcysteine amid reduces pancreatic damage in a rat model of acute necrotizing pancreatitis


TÜRKYILMAZ S., Usta A., ÇEKİÇ A. B. , Alhan E., Kural B. V. , Ercin C.

JOURNAL OF SURGICAL RESEARCH, vol.203, no.2, pp.383-389, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 203 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.1016/j.jss.2016.03.004
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.383-389
  • Keywords: NACA, N-acetylcysteine amid, Acute necrotizing pancreatitis, THIOL ANTIOXIDANT, OXIDATIVE STRESS, EPITHELIAL-CELLS, ACINAR-CELLS, PATHOPHYSIOLOGY, MECHANISMS, MEDIATORS, APOPTOSIS, PROTECTS, INJURY

Abstract

Background: Inflammatory explosion and oxidative stress are important mechanisms of injury in acute necrotizing pancreatitis (ANP). This study investigated the effects of N-acetylcysteine amid (NACA), a novel cell-permeant antioxidant with anti-inflammatory activity, on experimental ANP in rats.