Nephrology (Carlton, Vic.), vol.17, no.4, pp.372-9, 2012 (SCI-Expanded)
Article / Article
Nephrology (Carlton, Vic.)
Science Citation Index Expanded (SCI-EXPANDED), Scopus
apoptosis, cyclosporine, cyclosporine A-induced nephropathy, grape seed proanthocyanidin extract, nephropathy, oxidative stress, INDUCED NEPHROTOXICITY, OXIDATIVE STRESS, EXPERIMENTAL-MODEL, KIDNEY INJURY, RENAL INJURY, RATS, ACTIVATION, EXPRESSION, ACID, MICE
Karadeniz Technical University Affiliated:
Aim: Although the pathogenesis of cyclosporine (CsA) nephropathy is not completely understood, it is attributed to oxidative damage and apoptosis. Grape seed proanthocyanidin extract (GSPE) is a molecule with antioxidant and anti-apoptotic properties. Our aim was to demonstrate the effects of GSPE in preventing CsA nephropathy.