Anti-apoptotic and anti-oxidant effects of grape seed proanthocyanidin extract in preventing cyclosporine A-induced nephropathy

ULUSOY, ŞÜKRÜ; Özkan, Gulsum; YUCESAN, FULYA; ERSÖZ, ŞAFAK; ÖREM, ASIM; Alkanat, Mehmet; YULUĞ, ESİN; KAYNAR, Kubra; Al, Sait

doi:10.1111/j.1440-1797.2012.01565.x

Anti-apoptotic and anti-oxidant effects of grape seed proanthocyanidin extract in preventing cyclosporine A-induced nephropathy

Atıf İçin Kopyala

ULUSOY Ş. , Özkan G., YUCESAN F. , ERSÖZ Ş. , ÖREM A. , Alkanat M., ...Daha Fazla

NEPHROLOGY, cilt.17, ss.372-379, 2012 (SCI İndekslerine Giren Dergi)

Cilt numarası: 17 Konu: 4
Basım Tarihi: 2012
Doi Numarası: 10.1111/j.1440-1797.2012.01565.x
Dergi Adı: NEPHROLOGY
Sayfa Sayıları: ss.372-379

Özet

Aim: Although the pathogenesis of cyclosporine (CsA) nephropathy is not completely understood, it is attributed to oxidative damage and apoptosis. Grape seed proanthocyanidin extract (GSPE) is a molecule with antioxidant and anti-apoptotic properties. Our aim was to demonstrate the effects of GSPE in preventing CsA nephropathy.