Anti-apoptotic and anti-oxidant effects of grape seed proanthocyanidin extract in preventing cyclosporine A-induced nephropathy

ULUSOY Ş. , Özkan G., YUCESAN F. , ERSÖZ Ş. , ÖREM A. , Alkanat M., ...Daha Fazla

NEPHROLOGY, cilt.17, sa.4, ss.372-379, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Konu: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1111/j.1440-1797.2012.01565.x
  • Dergi Adı: NEPHROLOGY
  • Sayfa Sayıları: ss.372-379

Özet

Aim: Although the pathogenesis of cyclosporine (CsA) nephropathy is not completely understood, it is attributed to oxidative damage and apoptosis. Grape seed proanthocyanidin extract (GSPE) is a molecule with antioxidant and anti-apoptotic properties. Our aim was to demonstrate the effects of GSPE in preventing CsA nephropathy.