Anti-apoptotic and anti-oxidant effects of grape seed proanthocyanidin extract in preventing cyclosporine A-induced nephropathy.

ULUSOY Ş. , Özkan G., YUCESAN F. , ERSÖZ Ş. , ÖREM A. , Alkanat M., ...More

Nephrology (Carlton, Vic.), vol.17, no.4, pp.372-9, 2012 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1111/j.1440-1797.2012.01565.x
  • Title of Journal : Nephrology (Carlton, Vic.)
  • Page Numbers: pp.372-9
  • Keywords: apoptosis, cyclosporine, cyclosporine A-induced nephropathy, grape seed proanthocyanidin extract, nephropathy, oxidative stress, INDUCED NEPHROTOXICITY, OXIDATIVE STRESS, EXPERIMENTAL-MODEL, KIDNEY INJURY, RENAL INJURY, RATS, ACTIVATION, EXPRESSION, ACID, MICE

Abstract

Aim: Although the pathogenesis of cyclosporine (CsA) nephropathy is not completely understood, it is attributed to oxidative damage and apoptosis. Grape seed proanthocyanidin extract (GSPE) is a molecule with antioxidant and anti-apoptotic properties. Our aim was to demonstrate the effects of GSPE in preventing CsA nephropathy.