Copy For Citation
ULUSOY Ş., Özkan G., YUCESAN F., ERSÖZ Ş., ÖREM A., Alkanat M., ...More
Nephrology (Carlton, Vic.), vol.17, no.4, pp.372-9, 2012 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
17
Issue:
4
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Publication Date:
2012
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Doi Number:
10.1111/j.1440-1797.2012.01565.x
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Journal Name:
Nephrology (Carlton, Vic.)
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Page Numbers:
pp.372-9
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Keywords:
apoptosis, cyclosporine, cyclosporine A-induced nephropathy, grape seed proanthocyanidin extract, nephropathy, oxidative stress, INDUCED NEPHROTOXICITY, OXIDATIVE STRESS, EXPERIMENTAL-MODEL, KIDNEY INJURY, RENAL INJURY, RATS, ACTIVATION, EXPRESSION, ACID, MICE
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Karadeniz Technical University Affiliated:
Yes
Abstract
Aim: Although the pathogenesis of cyclosporine (CsA) nephropathy is not completely understood, it is attributed to oxidative damage and apoptosis. Grape seed proanthocyanidin extract (GSPE) is a molecule with antioxidant and anti-apoptotic properties. Our aim was to demonstrate the effects of GSPE in preventing CsA nephropathy.