Anti-apoptotic and anti-oxidant effects of grape seed proanthocyanidin extract in preventing cyclosporine A-induced nephropathy


ULUSOY Ş. , Özkan G., YUCESAN F. , ERSÖZ Ş. , ÖREM A. , Alkanat M., ...Daha Fazla

NEPHROLOGY, cilt.17, ss.372-379, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Aim: Although the pathogenesis of cyclosporine (CsA) nephropathy is not completely understood, it is attributed to oxidative damage and apoptosis. Grape seed proanthocyanidin extract (GSPE) is a molecule with antioxidant and anti-apoptotic properties. Our aim was to demonstrate the effects of GSPE in preventing CsA nephropathy.