Anti-apoptotic and anti-oxidant effects of grape seed proanthocyanidin extract in preventing cyclosporine A-induced nephropathy.

ULUSOY, ŞÜKRÜ; Özkan, Gulsum; YUCESAN, FULYA; ERSÖZ, ŞAFAK; ÖREM, ASIM; Alkanat, Mehmet; YULUĞ, ESİN; KAYNAR, RUKİYE; Al, Sait

doi:10.1111/j.1440-1797.2012.01565.x

Anti-apoptotic and anti-oxidant effects of grape seed proanthocyanidin extract in preventing cyclosporine A-induced nephropathy.

ULUSOY Ş., Özkan G., YUCESAN F., ERSÖZ Ş., ÖREM A., Alkanat M., ...Daha Fazla

Nephrology (Carlton, Vic.), cilt.17, sa.4, ss.372-9, 2012 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 17 Sayı: 4
Basım Tarihi: 2012
Doi Numarası: 10.1111/j.1440-1797.2012.01565.x
Dergi Adı: Nephrology (Carlton, Vic.)
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.372-9
Anahtar Kelimeler: apoptosis, cyclosporine, cyclosporine A-induced nephropathy, grape seed proanthocyanidin extract, nephropathy, oxidative stress, INDUCED NEPHROTOXICITY, OXIDATIVE STRESS, EXPERIMENTAL-MODEL, KIDNEY INJURY, RENAL INJURY, RATS, ACTIVATION, EXPRESSION, ACID, MICE
Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Aim: Although the pathogenesis of cyclosporine (CsA) nephropathy is not completely understood, it is attributed to oxidative damage and apoptosis. Grape seed proanthocyanidin extract (GSPE) is a molecule with antioxidant and anti-apoptotic properties. Our aim was to demonstrate the effects of GSPE in preventing CsA nephropathy.