Development and In Vitro Characterization of Oral Disintegrating Films Loaded with a Novel Hexahydroquinoline Compound
7th International Symposium on Pharmaceutical Chemistry, Ankara, Türkiye, 11 - 14 Haziran 2026, ss.1, (Özet Bildiri)
- Yayın Türü: Bildiri / Özet Bildiri
- Basıldığı Şehir: Ankara
- Basıldığı Ülke: Türkiye
- Sayfa Sayıları: ss.1
- Karadeniz Teknik Üniversitesi Adresli: Evet
Özet
Inflammation plays a critical role in the pathogenesis of numerous diseases, and its dysregulation may lead to chronic conditions. In addition to their antihypertensive effects, calcium channel blockers have been reported to exhibit anti-inflammatory properties (Tripathi, 2025).
In this context, a 1,4-dihydropyridine-derived hexahydroquinoline compound, coded as 3b, was previously synthesized by our research group, structurally characterized, and evaluated for its anti-inflammatory activity (Facchin, 2024). The compound demonstrated significant anti-inflammatory effects, likely mediated through a multitarget mechanism of action, rather than a single static pathway. The present study represents a continuation of this work and focuses on the development of an optimized formulation of compound 3b to improve its biopharmaceutical properties.
Based on promising results obtained from prior in vitro activity assays, a novel formulation strategy is being employed to enhance the compound’s absorption and release profile. This formulation-oriented approach aims to optimize the distribution and bioavailability of compound 3b, thereby potentially increasing its therapeutic efficacy in chronic inflammatory conditions.
ODFs represent an innovative drug delivery system that rapidly disintegrates in the oral cavity without the need for water, thus improving patient compliance and potentially increasing the bioavailability of drug candidates. In this study, ODF formulations containing compound 3b were prepared by the solvent casting method using hydroxypropyl methylcellulose (HPMC) as the film-forming polymer at three different concentrations: 3%, 4%, and 5% (w/v). Glycerin was used as the plasticizer, while citric acid, sodium saccharin, and peppermint flavor were incorporated to improve palatability and stimulate saliva production.
The prepared films were evaluated by in vitro characterization tests including organoleptic properties, thickness uniformity, pH, water absorption capacity, and disintegration time. Organoleptic evaluation showed that all formulations were homogeneous and transparent in appearance. The pH values of the reconstituted film formulations were found to be 6.15, 6.10, and 6.04 for the films containing 3%, 4%, and 5% HPMC, respectively. In addition, water absorption capacity increased with increasing polymer concentration, consistent with the hydrophilic nature of HPMC. In terms of disintegration performance, the 3% HPMC formulation disintegrated in less than 30 seconds, while the 4% and 5% HPMC formulations exhibited disintegration times between 30 and 60 seconds.