Akademik Veri Yönetim Sistemi
7. EBAT Congress, Antalya, Türkiye, 6 - 09 Kasım 2025, cilt.1, ss.23, (Özet Bildiri)
DNA plays a crucial role in the
diversity of cellular processes and serves as a primary target for the
treatment of diseases such as cancer and microbial infections. Therefore,
exhaustive research over the past four decades has focused on the effects of
small compounds that bind and break nucleic acids.1-2
In this study, the interaction of a previously
synthesized and characterized binuclear Cu (II) complex containing a Hydrazone Schiff Base with DNA
was examined using spectroscopic, electrophoretic and computational methods.
Spectroscopic DNA titration studies have shown that both ligand and the binuclear Cu (II) complex interact
with DNA. Additionally, electrophoresis studies revealed that the binuclear Cu (II)
metal complex cleaves DNA in both hydrolytic and oxidative manner. Finally,
the molecular docking findings demonstrated that the Cu (II)-complex
preferentially binds to the major groove of B-DNA with higher affinity and
stability compared to the minor groove. The results supported that this
complex may be a suitable agent for DNA-based drug development.
This study was supported by the TÜBİTAK 2209-A
Program (Application No: 1919B012402877). We would like to thank the TÜBİTAK
2209-A Program for their support.